The major thrust of the computational biophysics group led by Dr. Tuszynski is in silico drug design for cancer chemotherapy applications (as well as neurodegenerative diseases) and in vitro testing. One of the drugs (CCI-001) he designed is in clinical trials for metastatic bladder cancer. His research interests are strongly linked to the protein tubulin and the microtubules assembled from it. These have been studied using methods ranging from simple stochastic models to detailed molecular dynamics computer simulations, as well as through laboratory manipulations of living cells. Due to its prominent role played in eukaryotic cell division, tubulin is an important target for anti-cancer cytotoxic treatments. Other studies performed in group have examined microtubule electrical, electromagnetic, structural, and mechanical properties; as well as interactions with proteins that bind to microtubules (MAPs); and the motor proteins in cells that travel along microtubules and actin filaments. Additionally, his group has been developing physiologically-based models and simulations for pharmacokinetic and pharmacodynamic applications. More recently, he has focused his research efforts on the fundamental issues related to the role of quantum and electromagnetic effects on living systems and their higher functions including memory formation and consciousness.